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Int J Womens Health. Although the majority of the research on particulate drug delivery systems for vaginal drug delivery has focused on HIV prevention, there have been some examples of it being investigated for the localised treatment of cervical cancer. Vaginal rings for controlled release drug delivery. How does this happen? Staging classifications and clinical practice guidelines for gynaecological cancers. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Low-dose topical delivery of all-trans retinoic acid for cervical intraepithelial neoplasia II and III.

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Vaginal Drug Distribution Modeling

Topical 5-fluorouracil treatment of vaginal intraepithelial neoplasia. In contrast, TFV concentrations in epithelium are as much as one log higher than those in a biopsy for the first 4 hours after gel insertion data not shown. Precision medicine is another incentive for localised delivery, as this approach will require treatment with combination therapy to knockout the multiple molecular pathways that support cancer cell growth. Inthere was an estimateddeaths from cervical cancer worldwide [ 1 ]. Critical of the previous classification system, Querleu and Morrow devised their own in with the desire of providing a simpler, clearer approach that reduced excessive vaginal resection and comprehensively preserved more nerves [ 28 ].

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